标题:
The correlation between pulmonary fibrosis and methylation of peripheral Smad3 in cases of pigeon breeder’s lung in a Chinese Uygur population
讲者:
邬超
单位:
新疆维吾尔自治区人民医院
播放:
721
论文摘要:
We investigated the relationship between Smad3 gene methylation and pulmonary fibrosis in pigeon breeder’s lung (PBL). Twenty Uygur PBL patients with pulmonary fibrosis were enrolled. Twenty PBL-free pigeon breeders and 20 healthy non-pigeon breeders enrolled during the same period. Participants’ data and peripheral blood samples were collected, and three Smad3 CpG loci were examined.The CpG_3 methylation rate was significantly lower in the patient group than in the negative control group. Smad3 mRNA expression was significantly higher in the patient group. TGF-βlevels were significantly higher in the patient group than in either control group (both P<0.01). Smad3 gene methylation and Smad3 mRNA expression were negatively correlated. The number of pigeons bred during the preceding three months was positively correlated with Smad3 mRNA expression. Smad3 gene hypomethylation might promote pulmonary fibrosis in Uygur PBL patients via increased Smad3 mRNA expression.