标题:
Risk factors for secondary infections among hospitalized severe influenza A(H1N1)pdm09 patients
讲者:
周飞
单位:
中日医院
播放:
889
论文摘要:
Background: Secondary infection following influenza is one of the most important reasons of death that needs early implementations to prevent, but risk factors for secondary infection at early stage remained undetermined.
Objective: Our aim is to find risk factors that can help clinicians identify patients with high risk of secondary infections following influenza on admission.
Methods: Using database prospectively collected through a Chinese national network for severe influenza A(H1N1)pdm09 patients hospitalized between 1 September 2009 and 31 December 2009, we compared the characteristics on admission between patients with and without secondary infections. Logistic regression model was used to identify independent risk factors for secondary infections.
Results: In total, 2146 patients were enrolled in the final analysis with the mean age of 36.0 years, male 50.2%, and 225 patients (10.8%) complicated with secondary infections. A total of 57.2% of patients presented with viral sepsis on admission. ICU admission was 43.6%, invasive mechanical ventilation 18.6%, and in-hospital mortality 15.5%. The hospital mortality was much higher in patients with secondary infections than those without (45.7% vs 11.8%, P< 0.001). Acinetobacter baumannii (88/232, 37.9%) was the leading cause of secondary infection followed by Pseudomonas aeruginosa (10.8%) and Stenotrophomonas maltophilia (9.5%). The patients with viral sepsis (OR: 3.32; 95% CI 1.92-5.73) and lymphocytopenia (OR: 2.45; 95% CI 1.71-3.51) on admission were more likely to have secondary infections following influenza. Age>65 years (OR: 1.83; 95% CI 1.04-3.21), Anemia(OR: 1.39; 95% CI 1.39-2.79) and LDH>250U/L(OR: 1.21; 95% CI 1.21-3.04) and were also independent associated with secondary infections.
Conclusion: Viral sepsis and lymphocytopenia were independent risk factors that can help clinicians identify high-risk severe influenza A(H1N1)pdm09 patients of secondary infections. the patients with high risk of secondary infection following influenza at early stage.