标题:
Effect of age, comorbidity and adherence to current antimicrobial guideline on mortality in hospitalized community-acquired pneumonia patients over 65 years
讲者:
韩秀迪
单位:
青岛市立医院
播放:
1180
论文摘要:
Objective
Information is limited on clinical characteristics predictive of mortality in patients over the age of 65 years in many countries. This work investigates the impact of age, comorbidity and adherence to current antimicrobial guideline on mortality in hospitalized elderly community-acquired pneumonia (CAP) patients, in the context of the new adult Chinese CAP guidelines updated in 2016.
Methods
3,131patients aged ≥65 years were enrolled from a multi-center, retrospectively observational study initiated by the CAP-China network. Baseline characteristics and antimicrobial treatment regimen compared to current Chinese guidelines were evaluated for their mortality predictive value. Risk factors for 60-day mortality and overtreatment were evaluated in COX proportional hazards models and logistic regression respectively.
Results
The overall in-hospital and 60-day mortality were 5.7% and 7.3% respectively and were three-fold higher in those aged ≥85 years than those aged 65–74years (11.9% versus 3.2% for in-hospital mortality and 14.1% versus 4.7% for 60-day mortality, respectively; p<0.001 ). The independent predictors for 60-day mortality were age, long-term bedridden confinement, dementia, heart rate ≥125 beats·min-1, arterial oxygen saturation (SaO2)<90%, blood urea nitrogen (BUN) ≥11mmol·L-1, albumin<25g·L-1 and septic shock. 64% patients (1,411/2,207) received non-adherent treatment. For general ward patients, 51.2% were over-treated while 72.0% of intensive care unit (ICU) patients received under-treatment, according to the 2016 Chinese CAP guidelines.
Conclusion
Overtreatment in general wards patients and undertreatment in ICU patients were critical problems. Compliance with Chinese guidelines will require fundamental changes in standard-of-care treatment patterns. Data included herein may help physicians identify patients at increased risk of mortality early aiding in the choice of empiric initial antibiotic treatment in elderly CAP patients.