标题:
Imatinib–induced interstitial pneumonitis successfully switched to nilotinib in a patient with prior history of Mycobacterium tuberculosis infection
讲者:
罗专波
单位:
宁波市第一医院
播放:
689
论文摘要:
Abstract
Background: Chronic myeloid leukemia (CML) is a unique disease with a t(9;22) reciprocal chromosomal dislocation, which results in a aberrant gene formation of BCR-ABL. Imatinib mesylate (IM) is a selective inhibitor of BCR-ABL tyrosine kinase and has been proven to be an effective treatment of chronic myeloid leukemia. However, the drug has been associated with various adverse effects although such side effects are generally mild. Pulmonary complications may occur during imatinib therapy and most of pulmonary complications have been related to pleural effusion or pulmonary edema. Interstitial lung disease (ILD) associated with imatinib therapy is rare and there has been lack of data for specific risk factors to the development of IM-induced ILD.
Case Report: We report the case of a patient who had a prior treatment history of Mycobacterium tuberculosis infection and developed interstitial pneumonia after ten months of imatinib for CML. After the introduction of the recent tyrosine kinase inhibitor nilotinib and prednisone, the interstitial pneumonia has not relapsed.
Conclusion: Interstitial lung disease is a rare adverse event associated with imatinib therapy. To our knowledge, this case report is the first Chinese report of IM-induced ILD in a patient with a prior treatment history of Mycobacterium tuberculosis infection. Previous lung injuries might be associated with an increased risk of IM-induced ILD. The second-generation nilotinib appears to be the best alternative in cases of ILD induced by other tyrosine kinase inhibitors.