标题:
Higher tidal volume of ventilation improves lung function among patients with post-operative ventilator-associated pneumonia: Retrospective study of a clinical trial
讲者:
连宁芳
单位:
福建医科大学附属第一医院
播放:
895
论文摘要:
Background: There is an emerging trend of misusing low tidal volume (VT) ventilation in post-operative patients that causes ventilator-associated pneumonia (VAP), finally lead to the treatment failure. In this study, we evaluated the therapeutic value of high VT ventilation on perioperative VAP. Methods: A retrospective study was performed among patients enrolled in surgical intensive care unit. Perioperative VAP patients without underlying lung diseases received consultation from respiratory medicine experts and then were treated with high VT ventilation or conventional VT therapy as controls. All patients were followed up for 5-7 days after consultation. The peripheral white blood cell (WBC) counts, lung inflammation by chest X-ray exam, arterial blood gas concentration and parameters of respiratory functional test were analyzed. Results: A total of 50 patients were enrolled. We found that acute physiology and chronic health evaluation (APACHE II) score was comparable between the two groups. On day 5-7 day after treatment, compared to the patients treated with conventional treatment, patients received high VT ventilation have significant lower WBC counts that were decreased from 15.92 ± 2.82 to 10.60 ± 1.83 × 109/mm3 (p<0.001). In addition, the lung exudative lesions were decreased from 34.2 ± 9.1% to 25.8 ± 4.9% (p<0.001) in high VT ventilation group. Respiratory functional parameters including peak airway pressure, respiratory rate (RR), PaO2 were significantly improved (p<0.001), but PaCO2, pH value remained unchanged between the two groups. Conclusion: Appropriate high VT ventilation can rapidly improve hypoxemia and prevent post-operative patients with VAP, but without underlying other pulmonary infections.