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连宁芳:Higher tidal volume of ventilation improves lung function among patients with post-operative ventilator-associated pneumonia: Retrospective study of a clinical trial PPT讲座视频 中华医学会呼吸病学年会-2017(第十八次全国呼吸病学学术会议)
标题: Higher tidal volume of ventilation improves lung function among patients with post-operative ventilator-associated pneumonia: Retrospective study of a clinical trial
讲者: 连宁芳
单位: 福建医科大学附属第一医院
播放: 895
论文摘要: Background: There is an emerging trend of misusing low tidal volume (VT) ventilation in post-operative patients that causes ventilator-associated pneumonia (VAP), finally lead to the treatment failure. In this study, we evaluated the therapeutic value of high VT ventilation on perioperative VAP. Methods: A retrospective study was performed among patients enrolled in surgical intensive care unit. Perioperative VAP patients without underlying lung diseases received consultation from respiratory medicine experts and then were treated with high VT ventilation or conventional VT therapy as controls. All patients were followed up for 5-7 days after consultation. The peripheral white blood cell (WBC) counts, lung inflammation by chest X-ray exam, arterial blood gas concentration and parameters of respiratory functional test were analyzed. Results: A total of 50 patients were enrolled. We found that acute physiology and chronic health evaluation (APACHE II) score was comparable between the two groups. On day 5-7 day after treatment, compared to the patients treated with conventional treatment, patients received high VT ventilation have significant lower WBC counts that were decreased from 15.92 ± 2.82 to 10.60 ± 1.83 × 109/mm3 (p<0.001). In addition, the lung exudative lesions were decreased from 34.2 ± 9.1% to 25.8 ± 4.9% (p<0.001) in high VT ventilation group. Respiratory functional parameters including peak airway pressure, respiratory rate (RR), PaO2 were significantly improved (p<0.001), but PaCO2, pH value remained unchanged between the two groups. Conclusion: Appropriate high VT ventilation can rapidly improve hypoxemia and prevent post-operative patients with VAP, but without underlying other pulmonary infections.
 

呼吸内科

福建医科大学附属第一医院

福建医科大学附属第一医院呼吸与危重症医学科副主任,主任医师,教授,硕士研究生导师,主要从事慢性气道疾病、睡眠呼吸疾病等相关工作。

主要学术任职:

福建省医学会呼吸病学分会第六届委员会委员

福建省医师协会呼吸医师分会委员

福建省康复医学会呼吸康复专业委员会常委

中国老年医学学会呼吸病学分会重症学组委员


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作者: 连宁芳

单位: 福建医科大学附属第一医院

来源: 中国医师协会呼吸医师分会年会2019(CACP2019)暨第十八届中国呼吸医师论坛

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作者: 连宁芳

单位: 福建医科大学附属第一医院

来源: 中华医学会第十四次全国呼吸病学术会议

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