标题:
Plasma Leptin Is Elevated in Acute Exacerbation of Idiopathic Pulmonary Fibrosis
讲者:
曹孟淑
单位:
南京大学医学院附属鼓楼医院
播放:
883
论文摘要:
Background. The natural history of idiopathic pulmonary fibrosis (IPF) is very complex and unpredictable. Some patients will
experience acute exacerbation (AE) and fatal outcomes. Methods. The study included 30 AE-IPF patients, 32 stable IPF (S-IPF)
patients, and 12 healthy controls. We measured the plasma concentrations of leptin and KL-6. Simple correlation was used to
assess associations between leptin and other variables. Plasma leptin levels were compared between AE-IPF and S-IPF subjects,
decedents, and survivors. Kaplan-Meier curves were used to display survival and Cox proportional hazards regression was used
to examine risk factors for survival. Results. In subjects with AE-IPF, plasma leptin was significantly greater than in subjects with
S-IPF (p = 0.0003) or healthy controls (p < 0.0001). Plasma leptin was correlated with BMI, KL-6, LDH, CRP, and PaO2/FiO2
(p = 0.007; p = 0.005; p = 0.003; p= 0.033; and p = 0.032, resp.). Plasma leptin was significantly greater in 33 decedents than in
the 23 survivors (p = 0.007). Multivariate Cox regression analysis showed leptin (>13.79 ng/mL) was an independent predictor of
survival (p = 0.004). Conclusions. Leptin could be a promising plasma biomarker of AE-IPF occurrence and predictor of survival
in IPF patients.