论文摘要:
Objectives To characterize the association between BMI and all-cause mortality risk in Chinese hypertensive adults.
Methods We conducted a post-hoc analysis using data from the China Stroke Primary Prevention Trial (CSPPT), a study on hypertensive adults from 32 communities within Jiangsu and Anhui Provinces in China. Cox-regression analysis was performed to determine the significance of the association of BMI with all-cause mortality.
Results During a mean follow-up duration of 4.5 years, 622 deaths (3.0%) occurred among the 20,694 participants aged 45-75 years at baseline without history of stroke or myocardial infarction (MI). Among this population, a reversed J-shaped relationship was observed between BMI and all-cause mortality. Using Cox-regression analyses, the HRs for underweight (<18.5 kg/m2), overweight (24.0-27.9 kg/m2), and obesity (≥28.0 kg/m2) were calculated relative to normal weight (18.5-23.9 kg/m2). The summary HRs were 1.56 (95% CI, 1.11-2.18) for underweight, 0.78 (95% CI 0.64-0.95) for overweight and 0.64 (95% CI, 0.48-0.85) for obesity. In sex-age-specific analyses, participants over 60 years of age, had optimal BMI in the obesity classification and the results were consistent in both males and females.
Conclusions Relative to normal weight, underweight was associated with significantly higher mortality. Excessive weight was not associated with increased risk of mortality. Chinese hypertensive adults over 60 years of age without stroke or MI had the lowest mortality in grade 1 obesity.