标题：
The comparison of the pharmacologic effects on ACE2-Ang-(1-7)-MAS axis between ACEIs and ARBs
讲者：
陈永跃
单位：
广东省人民医院
播放：
2527
论文摘要：
Aims: Angiotensin converting enzyme 2-angiotensin-(1-7)-MAS axis [ACE2-Ang-(1–7)-MAS axis] is a novel axis of the Renin-Angiotensin- Aldosterone System (RAAS). The present study aimed at comparing the effects of angiotensin-converting enzyme inhibitors (ACEIs) and angiotensin receptor blockers (ARBs) on ACE2-Ang-(1–7)-MAS axis.
Methods: The essential hypertensive patients participating in this study were classified as ACEIs group and ARBs group according to the uses of agents. Their circulating levels of ACE2, Ang-(1-7) and Ang-(1-9) were measured by enzyme-linked Immunosorbent Assay (ELISA). Their circulating levels of aldosterone were measured by radioimmunoassay.
Results: There were 117 participants receiving ACEIs and 33 participants receiving ARBs. Overall, ACEIs group had the lower circulating levels of ACE2, Ang-(1–7) and Ang-(1–9) as compared with ARBs group (2200.786±3564.342 pg/ml versus 7880.276±6278.313 pg/ml, P<0.001; 457.748±386.137 pg/ml versus 1024.558±808.827 pg/ml, P<0.001; and 40.017±34.933 pg/ml versus 58.435±48.263 pg/ml, P=0.016; respectively, ANOVA). However, ACEIs group had the higher circulating levels of aldosterone (0.513±0.422 nmol/L versus 0.370±0.256 nmol/L, P=0.146; ANOVA). The Pearson correlation analysis showed that the circulating levels of aldosterone were inversely correlated with the circulating levels of ACE2 in ACEIs group or ARBs group.
Conclusions: There is a remarkable difference in the effects of ACEIs and ARBs on the circulating levels of ACE2-Ang-(1–7)-MAS axis. This finding suggests that ACEIs and ARBs may play a different pharmacologic role in the ACE2-Ang-(1–7)-MAS axis.
京公网安备 11011502002826号
