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Design and
method
Sixteen-weeks old female spontaneously hypertensive rats (SHR) (n=8) were
treated with irbesartan (Irb), benazepril (Ben) or vehicle for 12 weeks.
Wistar Kyoto (WKY) rats (n=8) receive vehicle. Echocardiography was performed
for evaluation of left ventricular structure, systolic and diastolic function
at 12 weeks. In order
to assess the process of oxidative stress, vascular remodeling and fibrosis, the
expression of transforming growth factor-β (TGF-β), Collagen type Ⅲ (Col Ⅲ) and endothelial nitric oxide synthase
(eNOS) in myocardial tissue were measured by western blot.
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Results
Systolic blood pressure demonstrated significant improvement in Irb rats or
Ben rats than in untreated SHR. No statistical difference was observed
between Irb rats and Ben rats in blood pressure. IVSd was significantly lower
in the Irb rats and Ben rats than untreated SHR (P=0.035, P=0.028,
separately). There was no difference in the LVEDD, LVEF and FS between SHR in
each group and WKY. E/A showed no statistical difference between groups. E/E’
decreased in Irb rats and Ben rats compared with untreated SHR (P=0.020,
P=0.039, separately). E’/A’ increased in Irb rats and Ben rats compared with
untreated SHR (P=0.032, P=0.041, separately). No statistical difference was
observed between Irb rats and Ben rats in blood pressure and echocardiographic
parameters (P＞0.05 for all). eNOS was decreased in untreated SHR, and
significantly increased in Irb rats and Ben rats. No difference was detected
in TGF-β between untreated SHR and WKY, however, It was declined under treatment
with irbesartan and benazepril (P=0.027, P=0.010, separately). Col Ⅲ was decreased in SHR (P=0.014), and increased in Irb
rats and Ben rats (P=0.028, P=0.007, separately) almost close to the level in
WKY. Among these two drugs, Benazepril resulted in better outcomes in eNOS, TGF-β
and Col Ⅲ. The
expression of eNOS was higher in Ben rats than Irb rats (P=0.028). TGF-β and Col Ⅲ were lower under benazepril than irbesartan (P=0.035, P=0.040, respectively). .
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Conclusions
Hypertension associated with diastolic dysfunction. Irbesartan and benazepril
provide therapeutic benefit in the blood pressure control , as well as
improvement of left ventricular hypertrophy and diastolic dysfunction. Although
Benazepril showed a little stronger suppression of oxidative stress and
fibrosis than irbesartan, there was no evidence of differential effects of
irbesartan and benazepril on the outcomes of left ventricular structure and
function.
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