标题:
Changes in Fragmented QRS Complex on Post-implantation Electrocardiography Associated with Left Ventricular Reverse Volumetric Remodeling in Cardiac Resynchronization Therapy
讲者:
李庆
单位:
昆明医学院第一附属医院
播放:
2883
论文摘要:
Background A fragmented QRS (fQRS) complex indicates inhomogeneous activation and asynchronous cardiac contraction. Changes in a fragmented QRS complex on post-procedural electrocardiography (ECG) indicating a summated signal of cardiac electronic activity may be predictive of the response to cardiac resynchronization therapy (CRT).
Methods A retrospective chart review was conducted on all patients who underwent CRT implantation at our institution between January 2013 and January 2016. Intrinsic ECG was recorded, and the biventricular-paced fQRS in the contiguous lead was calculated immediately after CRT and at the 6 month follow-up. The primary outcome was a decrease in left ventricular end-systolic volume of ≥15% compared to the baseline assessment, which was defined as left ventricular reverse volumetric remodeling.
Results A total of 68 patients (47 males; mean age, 57±11years) were included in this study. Thirty-eight patients responded to CRT at the 6 month follow-up.Biventricular-paced ECG was analyzed, and the changes in QRS width, the paced R in V1/V2, and changes in the fQRS and paced-fQRS were corrected in response to CRT.Reverse remodeling was observed in 13(34%) patients according to the changes in fQRS that were observed immediately after CRT and in 19 (50%) patients according to the changes in the paced fQRS observed at the 6 month follow-up (P<0.01). In the multivariate linear analysis, significant associations with the response to CRT were evaluated after adjusting for the etiology of cardiomyopathy, changes in QRS width, the paced R in V1/V2, and changes in the fQRS and paced-fQRS. Changes in the fQRS and paced-fQRS in response to CRT independently predicted left ventricular reverse volumetric remodeling (OR 4.696, 95% CI1.990-7.402; P=0.001 vs. OR 4.955, 95% CI 0.594-9.316; P=0.027).
Conclusions The presence of changes in the fQRS complex on post-implantation ECG associated with left ventricular reverse volumetric remodeling predicted CRT responsiveness.