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、TNF-α）表达水平。结果 腹主动脉瘤组CD4+ CD28-T细胞表达水平显著升高，其中CD4+ CD28-T细胞在小腹主动脉瘤组升高最为显著（P＜0.05）。Th1细胞因子（IFN-、TNF-α）表达水平亦呈显著升高，且与腹主动脉瘤直径呈正相关性。结论 不同发展阶段腹主动脉瘤患者血清中CD4+ CD28-T细胞表达升高，AAA患者外周血T淋巴细胞处于活化状态，在AAA发生发展的过程中，机体存在全身免疫反应的激活，外周血中T细胞亚组发生改变，导致炎症及自身免疫反应性扩展。 、TNF-αwere measured with enzyme-linked immunosorbent assays (ELISA). Result Compared with healthy controls, the serum level of CD4+ CD28-T cells and IFN-、TNF-αin AAA patients were higher than that in controls （P＜0.05）, the expression levels of IFN- 、TNF-αwe re positively correlated with the diameter of abdominal aortic. Conclusion Expression levels of CD4+ CD28-T cells and IFN- was significantly increased in AAA patients , suggesting a potential role of CD4+ CD28-T cells and IFN-on pathophysiology of AAAs, especially during the early development of AAAs.
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