会务通学术会议服务平台

标题： Air pollution and cardiovascular mortality in China, a systematic review and meta-analysis

讲者：梁恒瑞

单位：广州医学院

关键词：

Meta-analysis Air pollution Mortality China Cardiovascular health effect

播放： 2613

论文摘要： INTRODUCTION Air pollution levels in many Chinese cities remained much higher than the WHO guideline values in the past decades. Cohort evidence that stated the relationship between short-term effect of air pollution and cardiovascular health are still limited in China. We therefore conducted a meta-analysis summarizing the association between acute exposure of common air pollution and cardiovascular health.
METHODS We searched online databases PubMed, Web of Science, and Cochrane library only in English up to 2017.1.1, using the key words combinations of pollutants and cities in China. Outcomes were pooled and compared using random effects model. Cumulative meta-analysis was performed to evaluate the trend of pooled outcomes.We pooled the excess risks (ER) per 10μg/m3 of PM2.5, PM10, NO2, SO2 and O3. Subgroup analysis was conducted, especially according to lags day(lag0,1,2,0-1,0-2),gender (male vs. female),temperature (cool vs.warm) and age (<65 vs. ≥65).
RESULTS Of 299 identified articles in total, 30 satisfied inclusion criteria. Cardiovascular outcomes was associated with per 10 μg/m3 concentration increases in PM2.5 (0.68%, 95% CI 0.39-0.97％), PM10 0.39% (95% CI 0.26-0.53%), NO2 1.12% (95% CI 0.76-1.48%), SO2 0.75% (95% CI 0.42-1.09%), O3 0.62% (95% CI 0.33-0.92%) respectively. Cumulative meta-analysis suggested air pollutions had an increasingly severe impact on cardiovascular health in each group as time goes on. Strongest associations were seen on the lag0-1 of exposure among all pollutants. Subgroup analysis showed female, cool temperature and ages over 65 owned a higher risk than their counterparts in each pollutant.
CONCLUSIONS Our results reinforced that increasing in concentrations of common air pollutants led to a marked temporal association with cardiovascular mortality. Further high-quality and detailed studies in China are urgently warranted to evaluate the exposure response effect in order to determine the susceptible population, making relative policy to prevent the environmental health incidents.

梁恒瑞

胸外科

广州医科大学

学习工作经历
甘肃省兰州市第五十九中学                                                    09/2010-06/2013
广州医科大学临床医学南山班                                                 09/2013-06/2018
临床医学双语实验班，钟南山 院士担任班主任
台湾中山医学大学暑期交流(获“红日南山”国际游学奖学金资助)                          08/2014
香港大学李嘉诚医学院 PBL课程                                                         05/2015
广州医科大学附属第一医院、广州医科大学附属第二医院、广州市惠爱医院、广州市第八人民医院临床医学专业实习                                                                 01/2017-06/2018
AME 学术出版公司（AME Publishing Company）实习担任TLCR Section editor              11/2017
广州医科大学胸外科专业型研究生                                                   09/2018起
获得2018研究生“推免”资格，2018年9月入学；导师：广州医科大学附属第一医院院长 何建行 教授

获奖情况
广州医科大学英语技能大赛一等奖                                                2013-2014学年
广州医科大学“优秀学生干部”                                                   2014-2015学年
广州医科大学“优秀共青团干部”                                                 2014-2015学年
三等奖学金                                                                     2014-2015学年
“红日南山”科研奖学金                                   2014-2015、2015-2016、2016-2017学年
第4期“广医好故事”科研创新类获得者                                           2015-2016学年
单项奖学金科研类                                                               2016-2017学年
广州医科大学“挑战杯”大学生课外科技作品竞赛一等奖                                    4/2017
广东省“挑战杯”大学生课外科技作品竞赛三等奖                                          5/2017
中国国际心血管病学术会议（SCC2017）Oral presentation三等奖                            5/2017
Developing Country Travel Award winner for 2017 WCLC（世界肺癌大会游学奖金）            10/2017
2017广东大学生年度人物                                                                4/2018

参加会议报告
18^th World Conference on Lung Cancer (WCLC 2017)
Hengrui Liang, Difei Chen, Jianxing He, Wenhua Liang, Abstract # 10077 (Mini Oral presentation)
Hengrui Liang, Yuehan Chen, Jianxing He, Wenhua Liang, Abstract # 10108 (Poster)
第19届中国国际心血管病学术会议（19^th SCC）
Hengrui Liang, Difei Chen, Fengying Chen, Lei Zhao, Abstract # 498424 (Oral presentation)

任职
广州医科大学 2013级临床南山班班长                                            9/2013-9/2014
广州医科大学南山学院第一届学生会主席                                        9/2014-9/2015
广州医科大学第一临床学院学生会副秘书长                                      9/2014-9/2015
Translational Lung Cancer Research（TLCR） Section Editor                      11/2017-11/2018
The International Association for the Study of Lung Cancer（IASLC） Member         2/2018-2/2019

负责科研立项
校级重点资助项目《HIF-1/BMP4-TRPC信号通路在香烟烟雾致PAH中的作用机制》        9/2014-9/2015
广东省大学生科技创新培育专项资金立项项目“攀登计划” 普通课题                    9/2015-9/2016
国家“大学生创新创业训练计划项目” 普通课题                                      9/2015-9/2016

发表论文及专利

Liang, H., W. Liang, L. Zhao, et al., Robotic Versus Video-assisted Lobectomy/Segmentectomy for Lung Cancer: A Meta-analysis. [J] Ann Surg, 2017. doi: 10.1097/SLA.0000000000002346// 2017.06.20
Liang, H., W. Liang, L. Zhao, et al., Three-dimensional versus two-dimensional video-assisted endoscopic surgery: a meta-analysis of clinical data. [J] World J Surg, 2018 （Accepted）
Liang H, Huang J, Wang B, Liu Z, He J, Liang W. The role of liquid biopsy in predicting post-operative recurrence of non-small cell lung cancer. [J] J Thorac Dis 2018. doi: 10.21037/jtd.2018.04.08
Liang H, Pan Z, Wang W, Guo C, Chen D, Zhang J, Zhang Y, Tang S, He J, Liang W; written on behalf of AME Lung Cancer Cooperative Group. The alteration of T790M between 19 Del and L858R in NSCLC in the course of EGFR-TKIs therapy: a literature-based pooled analysis. [J] J Thorac Dis 2018. doi: 10.21037/jtd.2018.03.15
Liang H, Pan Z, Cai X, Wang W, Guo C, He J, Chen Y, Liu Z, Wang B, He J, Liang W; on behalf of AME Lung Cancer Cooperative Group. The association between human papillomavirus presence and epidermal growth factor receptor mutations in Asian patients with non-small cell lung cancer. [J] Transl Lung Cancer Res 2018. doi: 10.21037/ tlcr.2018.03.16
Zhao L*, Liang H R*, Chen F Y, et al. Association between air pollution and cardiovascular mortality in China: a systematic review and meta-analysis. [J]. Oncotarget, 2017, 8(39):66438-66448.
Yiyang Gao*,Hengrui Liang*, Luhao Liu et al. Comparison of Alpha-Blockers and Antimuscarinics in Improving Ureteral Stent-Related Symptoms: A Meta-Analysis.[J] Urology Journal 2018
Jianrong Zhang, Yiying Zhang, Hengrui Liang et.al Evaluation bias in objective response rate and disease control rate between blinded independent central review and local assessment: a study-level pooled analysis of phase III randomized control trials in the past seven years. [J] Ann Transl Med 2017.
Wenhua Liang, Yi Zhao, Weizhe Huang, Hengrui Liang et.al. Liquid biopsy for early stage lung cancer [J] J Thorac Dis 2018. doi: 10.21037/jtd.2018.04.26.
梁恒瑞,陈迪非,赵磊等.肺动脉高压发展过程中的信号转导机制[J].中华生物医学工程杂志,2014,20(5)
王璐陈凤英吴雄灏王念 梁恒瑞 赵磊.三种方法培养大鼠结肠平滑肌细胞的比较[J].中华生物医学工程杂志，2016,22（5）
赵磊陈凤英王璐吴雄灏 梁恒瑞 等.国内三甲基氯化锡中毒的系统性评价及meta分析[J].中华劳动卫生职业病杂志，2016,34(8)
陈凤英王念吴雄昊 梁恒瑞 赵磊等. 两种酶消化法培养小鼠气道平滑肌细胞的比较[J]. 中华生物医学工程杂志2017
赵磊王璐陈凤英 梁恒瑞 等一种可用于慢生长细胞培养的细胞培养皿（专利）实用新型专利；专利号：ZL 2015 2 0139891.9

演讲经历
广州医科大学第一临床学院新生代表演讲                                                  9/2013
钟院士“80寿辰暨行医60周年”做学生代表演讲                                             2016
广州医科大学第一临床学院优秀毕业生代表演讲                                            6/2018
广州医科大学毕业典礼学生代表演讲                                                      6/2018

活动参与
广州医科大学摄影大赛二等奖                                                    9/2013-9/2014
“广医大一院南山”篮球争霸赛团体第二名                                        9/2013-9/2014
“广医大一院南山”篮球争霸赛团体第三名                                        9/2014-9/2015
校园文化节开幕式爵士鼓（爵士鼓社团代表）表演                                             2016
参与接待多伦多大学教师访问团                                                            2016

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