论文摘要:
Background The
available data about effect of diabetes mellitus on clinical outcomes in
patients with STEMI after primary PCI
are limited. In addition, the effect of diabetes mellitus on left ventricular
function in patients with STEMI after
primary percutaneous coronary intervention (PCI) remains unknown so far.
Aim To investigate the impact of Diabetes
Mellitus on long-term mortality and left ventricular ejection fraction (LVEF)
in patients with acute ST-Segment Elevation Myocardial Infarction(STEMI)undergoing
primary percutaneous coronary intervention (PCI)
Design Retrospective
cohort study (total follow-up at least 3 years).
Patients and measurements we investigated 1,266 patients with STEMI and
treated with primary PCI. Patients were divided into 2 groups: Diabetic group and
Non- diabetic group. We study the long-term mortality
of patients after Primary PCI between the first 30 days and the 3 years
thereafter. Additionally, we analyzed the evolution of LVEF within 1 year.
Results Of
the 1266 STEMI patients, 196 (15.5%) had previously diagnosed diabetes.
Patients with diabetes were older and more likely to have prior cardiac history
including myocardial infarction, revascularization, and heart failure. Compared
with
Non-diabetic patients, patients with diabetes were significantly less likely to
achieve post-procedural TIMI 3 flow (P < 0.01). During 3-year follow-up,
patients with diabetes had higher early mortality(5.6%vs2.0%,P=0.0027), late mortality (8.2%vs4.6%, P=0.023) and overall
3-year mortality(13.8%vs6.6%,P= 0.0003) compared
to patients without diabetes. Furthermore, diabetes was associated with LVEF less
than 40% immediately after STEMI (odds ratio: 1.8 , 95% CI: 1.1 to 2.7, P
< 0.01) and a further decrease in LVEF within the first year (odds ratio: 1.9,
95% CI: 1.2 to 2.9, P < 0.01).
Conclusions The
presence of diabetes is associated with long-term mortality even when early
deaths are excluded from analysis. Furthermore, the presence of
diabetes is associated with reduced LVEF and further deterioration of LVEF in
the first year following Primary PCI.