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施国祥:Effect of Diabetes Mellitus on Long-Term Mortality and Left Ventricular Function in Patients With ST-Segment Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention PPT讲座视频 第18届中国南方国际心血管病学术会议
标题: Effect of Diabetes Mellitus on Long-Term Mortality and Left Ventricular Function in Patients With ST-Segment Elevation Myocardial Infarction After Primary Percutaneous Coronary Intervention
讲者: 施国祥
单位: The First Affiliated Hospital of Nanchang University
播放: 2691
论文摘要:

Background The available data about effect of diabetes mellitus on clinical outcomes in patients with STEMI  after primary PCI are limited. In addition, the effect of diabetes mellitus on left ventricular function in patients with STEMI  after primary percutaneous coronary intervention (PCI) remains unknown so far.

Aim To investigate the impact of Diabetes Mellitus on long-term mortality and left ventricular ejection fraction (LVEF) in patients with acute ST-Segment Elevation Myocardial Infarction(STEMI)undergoing primary percutaneous coronary intervention (PCI)

Design Retrospective cohort study (total follow-up at least 3 years).

Patients and measurements we investigated 1,266 patients with STEMI and treated with primary PCI. Patients were divided into 2 groups: Diabetic  group  and  Non- diabetic group. We study the long-term mortality of patients after Primary PCI between the first 30 days and the 3 years thereafter. Additionally, we analyzed the evolution of  LVEF within 1 year.

Results Of the 1266 STEMI patients, 196 (15.5%) had previously diagnosed diabetes. Patients with diabetes were older and more likely to have prior cardiac history including myocardial infarction, revascularization, and heart failure. Compared

with Non-diabetic patients, patients with diabetes were significantly less likely to achieve post-procedural TIMI 3 flow (P < 0.01). During 3-year follow-up, patients with diabetes had higher early mortality(5.6%vs2.0%,P=0.0027),  late mortality (8.2%vs4.6%, P=0.023) and overall 3-year mortality(13.8%vs6.6%,P= 0.0003)  compared to patients without diabetes. Furthermore, diabetes was associated with LVEF less than 40% immediately after STEMI (odds ratio: 1.8 , 95% CI: 1.1 to 2.7, P < 0.01) and a further decrease in LVEF within the first year (odds ratio: 1.9, 95% CI: 1.2 to 2.9, P < 0.01).

Conclusions The presence of diabetes is associated with long-term mortality even when early deaths are excluded from analysis. Furthermore, the presence of diabetes is associated with reduced LVEF and further deterioration of LVEF in the first year following Primary PCI.

心血管内科

南昌大学第一附属医院

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