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代子玄:Effects of the extrinsic cardiac nerve stimulation on atrial fibrillation inducibility: the regulation role of spinal cord nerve PPT讲座视频 第18届中国南方国际心血管病学术会议
标题: Effects of the extrinsic cardiac nerve stimulation on atrial fibrillation inducibility: the regulation role of spinal cord nerve
讲者: 代子玄
单位: 湖北省人民医院
播放: 1676
论文摘要:

Objective This study aimed to investigate the effect of the mutual regulation of extrinsic cardiac nerve on atrial electrophysiology and atrial fibrillation (AF) vulnerability.

Methods Sixteen dogs (12-15 kg) were randomly divided into 2 groups: low-level spinal cord stimulation (LL-SCS) group (n=8) and spinal cord block group (SCB, n=8). SCS was performed by 90% voltage of the threshold stimulating T1-T2 spinal level, while SCB was performed by injecting 2% lidocaine into epidural space at T2-3 level. Effective refractory period (ERP), ERP dispersion, AF inducibility and extrinsic cardiac nerve activity were measured during atrial pacing combine different extrinsic cardiac nerve stimulation.

Results ERPs were decreased and ERP dispersion was increased at left and right atrium and four pulmonary veins during left cervical vagus nerve stimulation (LVNS) and left stellate ganglion stimulation (LSGS) at baseline. ERPs were lower and ERP dispersion was higher during SCS combine LVNS than during LVNS, while ERPs were higher during SCS combine LSGS than during LSGS. SCS increased the induced AF episodes and AF duration during LVNS, while SCS decreased the induced AF episodes and AF duration during LSGS. ERPs were lower and ERP dispersion was higher during SCB combine LSGS than during LSGS. SCB increased the induced AF episodes and AF duration during LSGS. SCS enhanced the activity of left cervical vagus nerve, but attenuated the left stellate ganglion and superior left GP activity.

Conclusion The spinal cord nerve, as the “integration center”, modulates the extrinsic cardiac nerve activity between the cervical vagus nerve and stellate ganglion. SCS facilitates the effect of LVNS and attenuates the effect of LSGS in AF inducibility.

心血管内科

武汉大学人民医院

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