论文摘要:
Objective This study aimed to investigate the effect of the mutual
regulation of extrinsic cardiac nerve on atrial electrophysiology and atrial
fibrillation (AF) vulnerability.
Methods Sixteen dogs (12-15 kg) were randomly divided into 2 groups: low-level spinal cord stimulation (LL-SCS)
group (n=8) and spinal cord block group (SCB, n=8). SCS was performed by 90%
voltage of the threshold stimulating T1-T2 spinal level, while SCB was
performed by injecting 2% lidocaine into epidural space at T2-3 level. Effective
refractory period (ERP), ERP dispersion, AF inducibility and extrinsic cardiac
nerve activity were measured during atrial pacing combine different extrinsic
cardiac nerve stimulation.
Results ERPs were decreased and ERP dispersion was increased at left
and right atrium and four pulmonary veins during left cervical vagus nerve stimulation
(LVNS) and left stellate ganglion stimulation (LSGS) at baseline. ERPs were
lower and ERP dispersion was higher during SCS combine LVNS than during LVNS,
while ERPs were higher during SCS combine LSGS than during LSGS. SCS increased the induced AF episodes
and AF duration during LVNS,
while SCS decreased the induced AF episodes and AF duration during LSGS. ERPs were lower and ERP dispersion was
higher during SCB combine LSGS than during LSGS. SCB increased the induced AF episodes
and AF duration during LSGS.
SCS enhanced the activity of left cervical vagus nerve, but attenuated the left
stellate ganglion and superior left GP activity.
Conclusion The spinal cord nerve, as the “integration center”, modulates
the extrinsic cardiac nerve activity between the cervical vagus nerve and stellate
ganglion. SCS facilitates the effect of LVNS and attenuates the effect of LSGS
in AF inducibility.