标题:
The changes in Abdominal Aortic Calcification Index of patients receiving peritoneal dialysis using Bicarbonate/Lactate-buffered solution.
讲者:
Nanae Matsuo
单位:
Jikei University School of Medicine
播放:
1409
论文摘要:
Background Recently, new neutral peritoneal dialysis (PD) solution contained bicarbonate 25mEq/L and lactate 10mEq/L (Bic/Lac solution), instead of conventional neutral lactate 40mEq contained solution (Lac solution), could be utilizable in Japan. Until this point, PD patients had a higher level of sHCO3 (>25mEq/L) caused by the high concentration (40mEq/L) of lactate in existing Lac solution. Hence, the new Bic/Lac solution has been aimed to compensate excessive correction of metabolic acidosis by reducing total base concentration from 40mEq to 35mEq. We already reported that mean sHCO3 fell by 3mmol/L switched Lac solution to Bic/Lac solution. On the other hand, metabolic alkalosis is reported to increase vascular calcification. The aim of this study was to examine the effect of new Bic/Lac solution on Aortic Calcification Index (ACI) compared with Lac solution in peritoneal dialysis patients.
Materials and Methods A single-center prospective study was conducted. Among 46 patients, 28 patients were switched to Bic/Lac solution (mean 61 years, 79% male, 36% DM, mean PD vintage 3.2 years), and 18 patients continued using Lac solution (mean 65 years, 78% male, 11% DM, mean PD vintage 4.4 years). The patients’ ACI calculated by computed tomography scan were obtained before and after (6-12 months) the induction of Bic/Lac solution.
Results: The daily changes of ACI are 0.0082±0.0095%/day in Bic/Lac group, vs. 0.0133 ± 0.0167%/day in Lac group, respectively (P=0.39).
Discussion The new Bic/Lac PD solution is effective for overcorrection of metabolic acidosis in PD patients, although its benefit for vascular calcification was not significant in this study. The possible reasons for this result were that 6-12 months was too short to reach statistical significance and that influences of other factors (e.g. PTH, phosphate and so on.). Longitudinal follow up is needed to assess whether the Bic/Lac solution affects vascular calcification or not, in PD patients.