标题:
Serum Potassium Levels and Its Variability Associated with the Risk of the First Episode Peritoneal Dialysis-Related Peritonitis
讲者:
Chayutthaphong Chaisai
单位:
Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University, Thailand
播放:
1743
论文摘要:
Background Abnormal serum potassium has been consistently associated with an increased risk of all-cause mortality, cardiovascular and infectious mortality in peritoneal dialysis (PD) patients. However, evidences regarding the serum potassium profiles as a prognostic factor for PD-related peritonitis are scarce.
Objectives To investigate association of serum potassium profiles and the risk of the first episode PD-related peritonitis.
Methods A retrospective cohort was conducted using the PD registry database of patients aged > 18 years from a General Hospital, Chiang Mai, Thailand. We examined PD-related peritonitis predictability of serum potassium at baseline, time-averaged, and its variability in patients on PD for > 90 days between January 2008, and December, 2014 with follow-up through December 2015. Variability of serum potassium was defined as the coefficient of variation of serum potassium (CVSP) during PD treatment. The Cox’s proportional hazard model was used and presented with hazard ratio (HRs).
Results A total of 416 PD patients were included, 202 (48.6%) presented with hypokalemia (serum potassium < 3.5 mEq/L). After a total follow-up of 6,539.8 person-months, 239 (57.4%) patients experienced with the first episode PD-related peritonitis. Adjusted HRs of serum potassium level of < 3.5 and > 4.5 mEq/L, compared with 3.5-4.5 (reference) were 1.46 (95% CI, 1.02-2.10; P=0.040) and 1.03 (0.64-1.67; P=0.891), respectively for serum potassium at baseline, and 1.84 (1.13-2.99; P=0.013) and 0.76 (0.32-1.80; P=0.529), respectively for time-averaged serum potassium. According to the tertile of CVSP, the highest level of potassium level had substantially increased risk of the first episode PD-related peritonitis: adjusted HR 1.92 (95% CI, 1.09-3.38; P=0.024).
Conclusions A lower serum potassium level was an independently risk factor for the first episode PD-related peritonitis. Furthermore, higher variability of serum potassium levels contributed an increased risk of peritonitis. Serum potassium levels should be closely monitored in PD population.