标题:
THE ASSOCIATION BETWEEN COGNITIVE IMPAIRMENT AND ARTERIAL STIFFNESS IN PERITONEAL DIALYSIS PATIENTS
讲者:
易春燕
单位:
中山大学附属第一医院
播放:
1644
论文摘要:
Objective To investigate the association between cognitive impairment and arterial stiffness in peritoneal dialysis (PD) patients.
Methods This was a cross-sectional study. PD patients who followed up in our PD center from January 2014 to June 2016, aged more than 18 years and accepted PD treatment more than 3 months were recruited. The exclusion criteria were hearing or language impairment or dementia. The Montreal cognitive assessment (MoCA) was used to evaluated the cognitive function. The cognitive impairment was defined as MoCA less than 26 scores. Omron atherosclerosis detector was used to assessed brachial-ankle artery pulse wave velocity (ba-PWV) and ankle arm index (ABI).
Results Of 643 PD patients, mean age was 46.8±13.9 years, 57.9% of patients were male, and 13.1% with diabetes mellitus. The median vintage of PD was 27.8 (8.7-56.4) months. 321 (49.9%) PD patients had cognitive impairment. Compared with normal cognitive function group, patients with cognitive impairment had older age, higher proportion of female and diabetes mellitus, higher level of systolic blood pressure, high-sensitivity C-reactive protein, total cholesterol and triglyceride; lower education degree, diastolic blood pressure, serum albumin and serum calcium (all P<0.05). Patients with cognitive impairment also had higher BaPWV [1806.0(1562.0-2103.0) vs. 1562.0 (1415.8-1785.0) ; P<0.001], lower ABI (1.09±0.1 vs. 1.12±0.1; P<0.001). Logistic regression analysis showed that female [OR, 2.10 (95%CI, 1.33-3.31)], older age [OR, 1.04 (95%CI, 1.02-1.06)], accepted < 12 years education [OR, 2.80 (95%CI, 1.90-4.13)], diabetes mellitus [OR, 2.09 (95%CI, 1.11-3.95)], lower diastolic blood pressure [OR, 0.97 (95%CI, 0.95-0.99)], higher systolic blood pressure [OR, 1.02 (95%CI, 1.01-1.04)] and BaPWV [OR, 1.001(95%CI, 1.00-1.01)] were associated with cognitive impairment in PD patients after adjustment for confounders (all P<0.05).
Conclusions 49.9% PD patients had cognitive impairment in the present study. Higher BaPWV was significantly associated with cognitive impairment in PD patients.