标题:
Tertiary hyperparathyroidism and risk factors in patients undergoing peritoneal dialysis
讲者:
吉俊
单位:
复旦大学附属中山医院
播放:
1647
论文摘要:
Background and Objective Tertiary hyperparathyroidism (THPT) is a state of over-secretion of parathyroid hormone (PTH) after a long period of secondary hyperparathyroidism and resulting in parathyroid gland hyperplasia and adenoma.THPT is a rare disease which occurs most commonly in the setting of long-term hemodialysis or renal transplant. THPT in patients with CAPD has attacted less attention. The present study was conducted to determine the prevalence of THPT and the risk factors associated with this dysfunction in CAPD patients.
Methods The authors analyzed data of 452 patients who received CAPD between January 2010 and October 2016 at a single center of Zhongshan Hospital of Fudan University. Clinical data and laboratory variables related to parathyroid function were obtained from each patient. THPT was diagnosed when serum intact parathyroid hormone (iPTH) level was above 800 pg/ml, besides serum corrected calcium was above 2.7 mmol/L exclude non–drug-mediated hypercalcemia, and at least one parathyroid adenoma was revealed in Doppler ultrasound or 99mTc–(MIBI) parathyroid imaging. Variables predicting the development of THPT were calculated by univariate and multivariate logistic regression analysis.
Results THPT was identified in 9.3% of the CAPD patients (n=42).There were significant differences in the ratio of female gender, ages, PD duration, prevalence of hypertension and diabetes, serum corrected calcium concentration, iPTH levels, total Kt/V, total Ccr, residual GFR between THPT group and non-THPT group. Multiple logistic regression analysis showed that female patients (OR=2.73,95%CI1.83~3.90), long-term duration on CAPD above 5 years (OR=3.11,95%CI 1.80~5.14), non-diabetes (OR=4.23,95%CI2.44~7.21) and non-sufficient dialysis (OR=2.92,95%CI1.68~4.34)were the independent risk factors with the prevalence of THPT.
Conclusions THPT is not rare in the current Chinese CAPD population. Female, long duration on CAPD (>5 years), non-diabetes and non-sufficient dialysis are independent risk factors for the development of THPT in CAPD patients.