标题:
Risk of Peritoneal Dialysis-Related Peritonitis in Northern Thai Elderly Patients: An Era of “PD-First” Policy
讲者:
Kiatkriangkrai Koyratkoson
单位:
Department of Pharmaceutical Care, Faculty of Pharmacy, Chiang Mai University
播放:
1523
论文摘要:
Background Since 2008, the “Peritoneal-Dialysis-First (PD-First) policy was implemented in Thailand leading to a rapid growth of elderly PD cases. Owing to technical problems, social difficulties, and concomitant comorbid diseases, it remains controversial whether elderly patients have a substantially increased risk of peritonitis than their younger counterparts.
Objectives To assess the impact of increasing age on the risk of PD-related peritonitis.
Methods A retrospective cohort was conducted on the basis of data collected from the PD registry database at Kidney Center, General Hospital, Chiang Mai, Thailand. All adult patients commencing PD between January 2008, and December, 2014 were categorized into <55, 55-65, and >65 years of age groups, and followed until December 2015.Time to first PD-related peritonitis was analyzed using multivariable Cox proportional hazards model, and longitudinal peritonitis rates were analyzed by Poisson regression.
Results The cohort included 416 PD patients: 174 (41.8%) patients aged <55 years, 129 (31.0%) aged 55-65 years, and 113 (27.2%) aged >65 years. After a total follow-up of 6,539.8 person-months, 239 (57.4%) were identified as having PD-related peritonitis.Compared with younger patients (<55 years), older patientshad similar time to first peritonitis: adjusted hazard ratio (HR) = 0.93 (95% confidence interval, 0.66-1.31; P=0.678) for aged 55-65 years, and HR = 1.03 (0.66-1.60; P=0.907) for aged >65 years. Likewise, Poisson regression model yielded similar results: adjusted incidence rate ratio (IRR) = 1.03 (0.82-1.31; P=0.779) for aged 55-65 years, and IRR = 1.17 (0.86-1.59; P=0.325) for aged >65 years. There was no significant difference in spectra of causative microorganisms among patient age groups.In a subgroup analysis, we did not find any effect modification by patients’ characteristics and PD modality.
Conclusions Compared with younger patients, elderly patients have similar risk of peritonitis, suggesting that PD is a feasible modality for these populations.Large prospective trials are required to validate these association.