儿科PICU
中国医科大学附属盛京医院
Education:
2005.02-2005.04 Senior Visiting Scholar, Department of Pediatrics, University of Utah.
1992.09-1994.07 Ph.D. (Pediatric Cardiology), Jichi Medical University, Japan.
1985.09-1988.07 Master Degree (Pediatrics), West China Medical University, China.
1980.09-1985.07 Bachelor Degree (Clinical Medicine), West China Medical University, China.
Research Interest:
I have been specializing in Pediatric Intensive Care Medicine for nearly 30 years. I am good at diagnosis and treatment of common critical illness, especially sepsis, septic shock and ARDS. My primary research of interest is sepsis-induced myocardial dysfunction in children, and I have performed both clinical and basic researches for many years.
Administrative Positions: 1. The Director of Department of Pediatrics, the Director of Department of Pediatric Emergency Medicine, Shengjing Hospital of China Medical University. 2. The Director of Clinical Research Center of Children's Health and Disease of Liaoning Province. 3. The Director of Editorial Department of Chinese Pediatric Emergency Medicine. 4. The Member of the Standing Committee of Pediatrics of Chinese Medical Association, the Chairman of the First Aid Group of Pediatrics of Chinese Medical Association, and Vice Chairman of Pediatric Critical Care Medicine of Chinese Medical Association. 5. The Chairman of Pediatrician of Liaoning Medical Association, and Chairman of Pediatrics of Liaoning Medical Association. 6. The Chairman of Pediatric Critical Care Group of Inner Mongolia and Northeast area in China.
Managed the project (PI) 1. Construction of a platform for children's disease and health center.
Supported by Liaoning province key research and development plan guidance plan project
NO. 2017225003
Total costs for project period: 500,000 RMB
Project period: 1/1/18-12/31/20 2. Liaoning pediatric disease clinical medical research center.
Supported by Local professional technology innovation platform
NO. 2018108001
Total costs for project period: 500,000 RMB
Project period: 1/1/18-12/31/20 3. The role and regulation mechanism of β3-adrenoceptor in the model of sepsis-induced myocardial depression in rats.
Supported by the Natural Science Foundation of China
NO. 81372039
Total costs for project period: 700,000 RMB
Project period: 1/1/14-12/31/17 4. The regulation of autophagy in sepsis-induced myocardial depression in rats.
Supported by Liaoning planned project
NO. 2014225017
Total costs for project period: 600,000 RMB
Project period: 1/1/13-12/31/17 5. Changes of β-AR signaling pathway and cardiac dysfunction in sepsis rats
Supported by Natural Science Foundation of Liaoning province
NO. [2005]08
Total costs for project period: 50,000R MB
Project period: 1/1/05-12/31/08 6. Mechanism of systemic inflammatory response syndrome and multiple organ failure in critically ill children
Supported by Social Science Development Funding of Liaoning province
NO. [2001]88
Total costs for project period: 50,000 RMB
Project period: 1/1/01-12/31/03
Selected Publications (Corresponding author) 1. Wang W, Yang N, Wen R, Liu CF, Zhang TN. Long Noncoding RNA: Regulatory Mechanisms and Therapeutic Potential in Sepsis. Front Cell Infect Microbiol. 2021. 11:563126. 2. Zhang TN, Wen R, Yang N, Liu CF. Comparative transcriptome analysis of transcripts of uncertain coding potential in septic myocardial depression. BMC Cardiovasc Disord. 2021. 21(1):166. 3. Zhang TN, Wang W, Yang N, Huang XM, Liu CF. Regulation of Glucose and Lipid Metabolism by Long Non-coding RNAs: Facts and Research Progress. Front Endocrinol (Lausanne). 2020.11:457. 4. Zhang TN, Goodwin JE, Liu B, Li D, Wen R, Yang N, Xia J, Zhou H, Zhang T, Song WL, Liu CF. Characterization of Long Noncoding RNA and mRNA Profiles in Sepsis-Induced Myocardial Depression. Mol Ther Nucleic Acids. 2019. 17:852-866. 5. Zhang TN, Yang N, Goodwin JE, Mahrer K, Li D, Xia J, Wen R, Zhou H, Zhang T, Song WL, Liu CF. Characterization of Circular RNA and microRNA Profiles in Septic Myocardial Depression: a Lipopolysaccharide-Induced Rat Septic Shock Model. Inflammation. 2019. 42(6):1990-2002. 6. Zhang TN, Li D, Wu QJ, Xia J, Wen R, Chen XC, Yang N, Chen YL, Hang YH, Liu CF. Exposure to nitrogen oxide in the first trimester and risk of cardiovascular-related malformations: a dose-response meta-analysis of observational studies. Biomed Res Int. 2018; 2018: 1948407. 7. Xu W, Chen YL, Zhao Y, Wang LJ, Li JJ, Liu CF. A Clinical Study of Toxication Caused by Carbamazepine Abuse in Adolescents. Biomed Res Int. 2018; 2018:3201203. 8. Yang N, Shi XL, Zhang BL, Jian Rong, Zhang TN, Xu W, Liu CF The Trend of β3-Adrenergic Receptor in the Development of Septic Myocardial Depression: A Lipopolysaccharide-Induced Rat Septic Shock Model. Cardiology. 2018;139(4):234–244. 9. Yang N, Wu L, Zhao Y, Zou N, Liu CF. MicroRNA-320 involves in the cardioprotective effect of insulin against myocardial ischemia by targeting survivin. Cell Biochem Funct. 2018,36(3):166-171. 10. Zhang B, Liu CF, Yang N, Wang X. A comparative study of changes of autophagy in rat models of CLP versus LPS induced sepsis. Exp Ther Med. 2017;14(3):2194–2200. 11. Zhang TN, Li D, Xia J, Wu QJ, Wen R, Yang N, Liu CF. Non-coding RNA: a potential biomarker and therapeutic target for sepsis. Oncotarget. 2017;8(53):91765–91778. 12. Liu CF, Xiong X, Xu W, Sun J, Wang L, Li J. Serotypes and patterns of antibiotic resistance in strains causing invasive pneumococcal disease in children less than 5 years of age. PLoS One. ;8(1): e54254. 13. Xu W, Liu CF, Zhao Y, Li JJ, Wang LJ, Wen GF, Liu Z. Findings in children severely infected with a novel influenza A virus of swine origin: pulmonary imaging. World Journal of Pediatrics, 2012, 8(3):240-246. |