标题：
A clinical analysis of prognostic factors for dermatomyositis-associated interstitial lung disease
讲者：
张倜
单位：
第二军医大学附属长征医院
播放：
1783
论文摘要：
Objective Interstitial lung disease (ILD) is a common and life-threatening manifestation of dermatomyositis (DM).However, little is known about the factors influencing the prognosis for DM-ILD .The present study aimed to evaluate the characteristics and outcome of ILD in DM and to determine prognostic factors for DM-ILD.
Methods A retrospective analysis of DM-ILD was performed by survival analysis. The ILD-associated survival rates were estimated by using the Kaplan-Meier method to identify potential prognostic factors. Factors with P values ≤ 0.10 were subjected to multivariate analysis by Cox regression analysis. P values ≤ 0.05 were considered statistically significant.
Results A total of 103 DM patients with ILD were enrolled in the study. The mean follow-up period was 21.9 months (range, 2–120 months). The clinical presentation of ILD was acute/subacute form in 48 patients (46.6%) and chronic form in 55 patients (48.2%). The ILD-associated mortality was 34.9%. The statistical analysis suggested that aged over 60, acute/subacute form of ILD, heliotrope sign, ESR>20mm/h, CRP>10mg/L and hypocalcemia are independent predictors of poor outcome of DM-ILD. Moreover, negative correlations between serum calcium and levels of CRP, ESR were found in DM-ILD.
Conclusions: Aged over 60, acute/subacute form of ILD, heliotrope sign, ESR>20mm/h, CRP>10mg/L and hypocalcemia predict poor outcome in DM-ILD patients. And level of serum calcium may prove to be an inflammatory biomarker in DM-ILD patients.
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