标题：
Can women who were treated with fertility-sparing surgery for nonepithelial ovarian tumors safely and successfully become pregnant?—A Chinese retrospective cohort study of 148 cases
讲者：
杨斌
单位：
华中科技大学同济医学院附属同济医院
播放：
5674
论文摘要：
This study was undertaken to evaluate the oncologic outcomes and reproductive outcomes of childbearing age women who were treated with fertility-sparing surgery (FSS) for nonepithelial ovarian tumors in China. One hundred and forty eight nonepithelial ovarian tumors women treated with FSS between 1 January 2000 and 31 August 2015 from two medical centers in China were identified. Progression-free survival (PFS) was 88.5% and overall survival (OS) was 93.9%. Univariate analysis suggested that only delivered or not after treatment is related to PFS (P=0.023), while histology significantly influenced OS. A COX regression analysis suggested that only histology was associated with PFS and OS (P＜0.05). One hundred twenty nine (129) women who completed adjuvant chemotherapy (ACT), none developed amenorrhea. Among 44 women who desired pregnancy, 35 (79.5%) successfully had 51 gestations, including 35 live births without birth defects. Nonepithelial ovarian tumors can achieve fulfilling prognosis after FSS and chemotherapy. Only histology might be an independent prognostic factor for PFS and OS. FSS followed by ACT appeared to have little or no effect on fertility. Meanwhile, postoperative pregnancy did not increase the PFS or OS. The use of GnRH-a didn’t show benefit for fertility.
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