标题:
Cumulative live birth rates and related factors of in vitro fertilization / intracytoplasmic sperm injection-embryo transfer in PCOS patients in late reproductive years
讲者:
肖知英
单位:
郑州大学第三附属医院河南省妇幼保健院
播放:
876
论文摘要:
Objective: To assess whether women with polycystic ovary syndrome (PCOS) get the same cumulative live birth rates(CLBRs) in their first IVF/ICSI stimulation cycles(including first fresh cycle and following frozen cycles) as women with tubal factor infertility over the reproductive life span. PCOS is characterized by increased ovarian reserve as assessed by antral follicle counts (AFC) and anti-Mullerian hormone levels. It is unclear whether these surrogate markers of ovarian reserve reflect a true lengthening of the reproductive window or a better IVF/ICSI outcomes.
Design: Retrospective cohort.
Setting: Not applicable.
Patient(s): Women with PCOS and tubal factor infertility (900 patients). Intervention(s): IVF/ICSI.
Main Outcome Measure(s): cumulative live birth rates.
Result(s): The mean number of transferable embryos was higher in women with PCOS compared with in infertility women with tubal factor. There was no significant difference between the two groups in live birth rate of fresh cycle). Comparisons between PCOS and control group did not reveal any significant difference for the CLBRs of advanced age (above 35 years) (47.33% vs. 45.50%).
Conclusion(s): Despite a higher transferable embryos in advanced age group, women with PCOS over age 35 had similar CLBRs compared with women with tubal factor infertility. These findings suggest that the reproductive window may not be extended in PCOS patients and they should be treated in a timely manner despite indicators of higher ovarian reserve.