标题:
Comparison of perinatal outcomes following blastocyst stage vs cleavage stage embryo transfer: 10 years data analysis from a single center
讲者:
施文浩
单位:
西北妇女儿童医院
播放:
942
论文摘要:
Objective
To evaluate the risk of perinatal outcomes and congenital malformations after blastocyst transfer compared with cleavage stage embryo transfer in IVF
Design
This was a retrospective cohort analysis form an ART center in a public hospital of China. All conceived women (15,254) and newborns (16,213) from IVF/ICSI cycles with cleavage embryo transfer or blastocyst transfer were included during 2006–2015. Outcome measurements included congenital malformations, preterm birth, low birth weight, small for gestational age and large for gestational age.
Results
After logistic regression analysis by adjusting for 12 factors, the very preterm birth rate (<32 weeks) was higher in blastocyst transfer (P=0.037; Adjusted OR, 2.07; 95%CI 1.05-4.10) compared with cleavage stage embryo transfer, as well as sex ratio imbalance toward males in the neonates after blastocyst transfer (P=0.001; Adjusted OR, 1.17; 95%CI 1.07~1.30). There were no differences of miscarriage, ectopic pregnancy, stillbirth, PTB (<37 weeks), LBW, small for gestational age (SGA) and large for gestational age (LGA) between blastocyst transfer and cleavage stage embryo transfer. A total of 176 congenital malformations (123 cleavage stage embryos vs. 53 blastocysts) were identified both in newborns and aborted fetuses, in which no significant difference was showed.
Conclusions
In addition of a higher risk of very preterm birth and sex ratio imbalance toward males in the neonates after blastocyst transfer, there was no other risk of adverse perinatal outcome and congenital malformation after blastocyst transfer compared with cleavage stage transfer.